IIBBA   05544
INSTITUTO DE INVESTIGACIONES BIOQUIMICAS DE BUENOS AIRES
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
A Local Network Activated by Experience Accelerates the Integration of New Dentate Granule Cells
Autor/es:
SUNG M. YANG; KARINA A. BÜTTNER; DIEGO D. ALVAREZ; SILVIO G. TEMPRANA; DAMIANA P. GIACOMINI; MARIELA F. TRINCHERO; ALEJANDRO F. SCHINDER
Lugar:
Buenos Aires
Reunión:
Congreso; 2do congreso de la Federación de Sociedades de Neurociencias de Latinoamérica y el Caribe (FALAN) 2016; 2016
Institución organizadora:
Autoridades de FALAN junto con el Consejo Directivo de la Sociedad Argentina de Investigación en Neurociencias
Resumen:
Adult-born dentate granule cells (GCs) develop and integrate into the local networks in a process that lasts several weeks. It has been shown that the level of activity of local networks correlates with the speed of maturation of adult-born GCs. Here we show that developing GCs in the adult mouse hippocampus display a critical period previous to the onset of glutamatergic synaptogenesis whereby they are prone to modulation by activity. When mice were exposed to enriched environment for two days, GCs undergoing this critical period displayed accelerated maturation and functional integration, as revealed by morpho-functional analysis of retrovirally-labeled cells. Accelerated integration was also found upon direct activation of new GCs in vivo during the critical period using synthetic DREADDs (Designer Receptors Exclusively Activated by Designer Drugs). In addition, activation of mature GCs by means of the hM3Dq receptor was used to monitor the influence of local circuits on developing GCs. Indeed, in vivo activation of mature GCs by the synthetic ligand accelerated the integration of developing GCs. In agreement with recent works, we propose that parvalbumin-expressing GABA interneurons (PV) are responsible of controlling neuronal maturation. Interestingly, activation of PV interneurons or mature GCs in acute slices induced a postsynaptic response in developing neurons undergoing the critical period. Our results suggest that during cognitive tasks, GCs activate PV interneurons, which, in turn, promote functional recruitment of new cohorts of developing GCs.