IDENTIFICATION ON PUTATIVE LxCxE MOTIFS TARGETING THE RETINOBLASTOMA PROTEIN IN HUMAN VIRUSES BY STRUCTURE- AND SEQUENCE-BASED CALCULATIONS

GLAVINA, J; CHEMES, L.B.; DE PRAT-GAY, G.; SANCHEZ, IE

Basel

Congreso; ECCB12 11th European Conference on Computational Biology; 2012

Swiss Institute of Bioinformatics and International Society for Computational Biology

Many protein functions can be described in terms of “linear sequence motifs” of less than five functiondetermining residues. The Lx[CS]x[ED] motif (Figure 1) interacts with the retinoblastoma tumor suppressor (Rb), which plays a key role in cell cycle progression. The Lx[CS]x[ED] motif was identified in several proteins from oncogenic and teratogenic RNA and DNA viruses (Table 1). In addition, activity modulation suggesting the Lx[CS]Sx[ED] motif may be present in other viral proteins. We have developed a method to identify novel Rb-protein Lx[CS]x[ED] motifs in viral proteins using a combination of structure- and sequence-based calculations.