Evolution of linear motifs within the intrinsically disordered and globular domains of the papillomavirus E7 oncoprotein

CHEMES, L.B.; GLAVINA, J; FAIVOVICH JULIAN; ALONSO, L.G.; MARINO BUSLJE, C; DE PRAT-GAY, G.; SANCHEZ, IE

Santiago

Congreso; 3rd ISCB (International Society for Computational Biology) Latin American Meeting; 2012

International Society for Computational Biology

Linear motifs mediate many protein functions. We studied conservation and evolution of eight linear motifs within the intrinsically disordered (E7N) and globular (E7C) domains of the papillomavirus E7 protein using 200 sequences. E7N and E7C show similar conservation, which is explained by the globular structure of E7C and by the conserved and coevolving linear motifs in E7N. Several motif pairs show high co-occurrence, suggesting that they form functional and evolutionary units. Multiple independent appearances of several motifs during papillomavirus evolution provide direct evidence for convergent evolution, which may play an adaptive role as shown by correlation with phenotype.