INTEMA   05428
INSTITUTO DE INVESTIGACIONES EN CIENCIA Y TECNOLOGIA DE MATERIALES
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
Preliminary studies of electrospun guar gum scaffolds for drug controlled delivery
Autor/es:
ARUP MUKHERJEE; GERMÁN A. ISLAN; GUILLERMO R. CASTRO; PABLO R. CORTEZ TORNELLO; GUSTAVO A ABRAHAM
Lugar:
La Plata
Reunión:
Workshop; International workshop on drug design and neglected tropical diseases; 2016
Institución organizadora:
UNLP
Resumen:
In this work, GG nanofibrous scaffolds were obtained by electrospinning technique from polymer aqueous solutions (1.5 % w/v) with different amounts of aqueous solution of trisodium trimetaphosphate (STMP) 30 % w/v (5, 8 and 10 % v/v respectively). STMP was used as crosslinker, reducing the swelling. GG scaffolds were characterized in terms of fiber diameter (as measured by scanning electron microscopy - SEM), thermal properties (differential scanning calorimetry - DSC), swelling degree in sodium chloride solutions, and surface composition (Fourier transform infrared spectroscopy - FTIR).Nonwoven nanofibrous scaffolds were formed by uniform bead-free fibers with mean diameters of 56 ± 12 nm. The thermal results showed that the crosslinked GG scaffolds present present higher glass transition temperature and and gelatinization enthalpy, probably due to the higher crosslinking. Crosslinking decreases swelling degree (buffer intake) of GG, and then drug release from drug-loaded matrices could be controlled by increasing STMP concentration.