Biopolymeric particles: Promising carriers for peptide delivery

MÓNICA GARCÍA; MERARI CHEVALIER; VERA ALVAREZ; ALVARO JIMENEZ KAIRUZ; DANIELA GONZALEZ

Salamanca

Congreso; BIO IBEROAMERICA 2016; 2016

The administration route is highly relevant in defining nanoparticles transport kinetics and delivery efficiency. Systemic drug administration enables the active pharmaceutical ingredient (API) to distribute throughout the entire body, which is currently state-of-the-art for the treatment of various severe diseases [1]. Broadly speaking, common routes of administration of nanoparticles include oral, intravenous, subcutaneous, intradermal, intramuscular, nasal, and pulmonary injections, each with corresponding applications and distinctive features [1, 2]. Among differente kinds of administration routes, intravenous administration is the most frequently used for targeted delivery of nanoparticles. These ones after intravenous administration are circulating throughout the body and they escape the circulatory system to other tissues by endocytosis, shear forces, or passive diffusion through fenestrations in the capillary network [3]. In this sense, there has been an increasing attention in the development of nanoparticle drug carriers which are small enough for intravenous administration and possess a suitable bloodstream half-life in order to enable drug release into the vascular compartment in a continuous and controlled way [4].