Electrospun mats of cyclodextrin-based polymers for antifungal treatment

A. COSTOYA MUJICO; F. MONTINI BALLARIN; G.A. ABRAHAM; A. CONCHEIRO; C. ÁLVAREZ-LORENZO

Santiago de Compostela

Otro; IX Foro Internacional Cátedra Iberoamericana-Suiza de Desarrollo de Medicamentos (CISDEM 2015); 2015

Universidad de Santiago de Compostela, España

Electrospinning is a versatile technique to produce functionalfibers with diameters ranging from nano- tomicrometers that have been extensively explored as drug carriersdue to high loading capacity and highencapsulation efficiency to achieve sustained drug releaseprofiles [1]. Water-soluble cyclodextrin-basedpolymers (polyCDs), prepared via cross-linking of CD units withEpichlorohydrin (EPI), exhibit higher aqueous solubility and low toxicity thanparent CDs that make them very interesting in biomedical field. Furthermore, theypresent properties from CD units like improvement of solubility, stability andbioavailability of hydrophobic drugs through host-guest inclusion complexes(IC) to facilite the release of drugs [2].The aim of this work was to implement an electrospinning procedureto obtain fibers from polyCDs, formingcomplexes with fluconazole (FLU), mixed with poly-(å-caprolactone) or poly(N-vynilpyrrolidone) for sustained drugrelease.