Characterization of Polyvinyl alcohol Pectin cryogel for transdermal delivery?

YANINA MARTINEZ; JIMENA GONZÁLEZ; VERA ALVAREZ; GUILLERMO CASTRO

Bariloche

Encuentro; XIV Encuentro de Superficies y Materiales Nanoestructurados; 2014

Polyvinyl alcohol (PVA) and polyvinyl alcohol-pectin (PVA-P) cryogels are potential devices for wound treatment. These materials have advantages over commercial wound dressings such as: avoiding wound infection and retaining an appropriate level of moisture around wound. Moreover, in the case of cryogels for drug delivery, these materials have antibacterial performance exploited to the development of wound dressing. In previous work, the development of PVA-P cryogels with flouroquinolone enrofloxacin and keratinase have been studied in infected areas with promising results. In this work, an exhaustive chemical, morphological and physical characterization of these films was carried out. The results show that the presence of pectin in PVA cryogel increase the size of PVA nanodomains determined by X-ray diffraction (XRD) patterns indicating an interaction between both PVA and pectin polymers. SAXS analysis showed changes in 1 nm in PVA nanodomains when enrofloxacin and keratinase were immobilized into PVA-P cryogels. These results suggest the incorporation of both the enzyme and enrofloxacin into the polymeric matrix. A model involving the complex formation between the enzyme and enrofloxacin allocated through and between PVA nanodomains is proposed and it is well-correlated with results obtained in previous work where enrofloxacin kinetic release was found retarded by the presence of keratinase in the cryogels.