INTEMA   05428
INSTITUTO DE INVESTIGACIONES EN CIENCIA Y TECNOLOGIA DE MATERIALES
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
A simple novel mechanical setup for measurement the flexural modulus of femurs of mice in a model of dietary Ca absorption
Autor/es:
MONTINI BALARIN, FLORENCIA; PIETRANI, FABRICIO; VINDEROLA, GABRIEL; ABRAHAM, GUSTAVO; FRONTINI, PATRICIA
Lugar:
Puerto Iguazú
Reunión:
Congreso; 13er Congreso Internacional en Ciencia y Tecnología de Metalurgia y Materiales SAM/CONAMET 2013; 2013
Institución organizadora:
IMAM - CONICET / PROVALOR - CYTED / RIADICYP / VTT
Resumen:
Mouse models have been used to study the effects of genetic mutations, functional foods, changes in loading, and chemical treatments on changes in the biomechanical properties of bones. Therefore, it is important to have a reliable setup to measure the mechanical properties correctly. Considering the sample dimensions (diameter < 2mm, length < 14 mm) it is a challenge to acquire both load and displacement in an instrumented way. Furthermore, the sample geometry requires an image analysis to calculate the mechanical properties. New machines, like nano/micro universal testing machines, may offer a solution to the problem but, in the lack of this kind of sophisticated equipments, new ingenious setups may successfully replace them. In this work, a novel setup based on a cantilever beam configuration was chosen to measure the elastic modulus of the bones and failure load. Grips were tailor made to adapt to the universal testing machine INSTRON. On one side, a device to embed horizontally a poly(methylmetacrilate) (PMMA) 1x0.9x2.9 cm prism (where the femur was fixed) was constructed. For the moving grip, a triangular prism was built to apply the force to the femur free ending. The displacement was measured with a video extensometer. The measured femur elastic modulus was 13.89 ± 5.93 GPa and the failure load was 4.40 ± 1.05 MPa. These results agreed with data reported in the literature (satisfying the Student?s t-test (p< 0:05)), proving that this setup is suitable for mice femur mechanical characterization.