CONICET | Buscador de Institutos y Recursos Humanos

Nowadays, targeted delivery of drug molecules to specific sites represents a big challenge for researchers in pharmaceutical sciences. A new frontier in the field of biomedical technologies was opened by the developing of drug delivery devices such as, liposomes, micelles, dendrimers, micro and nanoparticles. All these drug delivery systems (DDS) attempt to improve the therapeutic effect of drugs mainly by improving their biodistribution and modulating drug release. Within all the drug delivery systems, nanoparticles present numerous advantages, mainly associated to their special characteristics, such as, small particle size, large surface area and huge versatility to customize and personalize their surface. Polymeric nanoparticles made from biodegradable or non- biodegradable, synthetic or natural polymers, represent one of the most relevant drug delivery vehicles nowadays due to their capability to modulate drug release effectively, improve encapsulation and bioavailability and decrease toxic side effects.. This work attempt to synthesize and characterize polymeric nano and microparticles made from polycaprolactone and from polyvinyl alcohol as drug carriers.