Random and Aligned Platelet-Rich Plasma (PRP)-poly-(l-lactic acid) (PLLA) electrospun fibers as scaffolds for tissue engineering

L. DIAZ-GOMEZ; F. MONTINI BALLARIN; G.A. ABRAHAM; A. CONCHEIRO; C. ALVAREZ-LORENZO

Madrid

Conferencia; 25th European Conference on Biomaterials; 2013

European Society of Biomaterials

Platelet-rich plasma (PRP) could be incorporated into implantable devices enhancing its bioactivity1. Recently, electrospun fibers of PRP solely enabled controlled release of growth factors and increased cell proliferation and infiltration into the scaffold2. Moreover, aligned architecture may improve cell orientation in tissues with a specialized direction3. The aim of this work was to obtain random and aligned PRP:PLLA scaffolds and evaluate the alignment and PRP effect on mesenchymal stem cells (MSC).