Microfibrous bioresorbable polymeric matrix containing dispersed antifungal agents

P.R. CORTEZ TORNELLO; G.E. FERESIN; A. TAPIA; G.A. ABRAHAM; T.R. CUADRADO

Mar del Plata, Argentina

Taller; 2º Workshop in Artificial Organs, Biomaterials and Tissue Engineering, OBI 2011. XVIII Congreso Argentino de Bioingeniería y VII Jornadas de Ingeniería Clínica; 2011

Universidad Nacional de Mar del Plata, Sociedad Argentina de Bioingenieria (SABI), Sociedade Latino Americana de Biomateriales (SLABO)

In order to decrease the unwanted secondary effects to systemic levels generated by oral administration of antifungal drugs for fungal epithelium diseases, antimycotic agents loaded polymeric systems were developed and characterized. Polymer meshes were prepared by solubilizing Chalcona 1 (Ch1) and Ketoconazol (Keto) in poly(lactide-co-glycolide) (PLGA 50:50) and Mw 54 KDa. Chalcona 1 is an active natural agent poorly soluble in water which exhibits fungical activity. Ketoconazole is a commercially available drug used to treat fungal and yeast infections. Both agents were selected to prepare drug-loaded fibrous meshes by electrospinning process. The resulting microfibrous meshes were characterized by differential scanning calorimetry, scanning electron microscopy, and ultraviolet-visible spectroscopy. Thermal analysis showed that both Ch1 and Keto were completely dissolved in amorphous PLGA meshes. Ch1 and Keto content incorporated to the PLGA/Ch1 and PLGA/Keto systems was 77.87 and 104.15 mg/g mesh, this load being useful for topical applications.