INTEMA   05428
INSTITUTO DE INVESTIGACIONES EN CIENCIA Y TECNOLOGIA DE MATERIALES
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
POLYVINILALCOHOL HYDROXIAPATITE HYDROGELS OBTAINED BY TWO DIFFERENTS TECHNIQUES CHARACTERIZATION AND SWELLING STUDIES.
Autor/es:
JIMENA GONZÁLEZ; VERA ALVAREZ; YANINA MINABERRY
Reunión:
Congreso; 2º Taller de Órganos Artificiales, Biomateriales e Ingeniería de Tejidos; 2011
Resumen:
The applications of Poly (vinylalcohol)/hydroxiapatite hydrogels (PVA/HA) have been extended to the replacement of diseased or damaged articular cartilage, due to its good physicochemical and especially tribological properties. The main objective of this work was to obtain PVA/HA hydrogels, with “in situ”generated HA by two different techniques: F/T (freezing/ thawing) and ISISA (ice-segregation-induced self-assembly) techniques. For this purpose, morphological, chemical, thermal, mechanical and swelling analyses were carried out. The F/T method consist of: freezing (-18ºC) a solution of PVA with Ca(OH)2 and H3PO4 (stochiometric rate to precipitate HA) and thawing this solution (25ºC), repeating that F/T cycle 3 times in order to crosslink the polymer. The ISISA process involves the submission of an aqueous gel, solution or suspension to liquid-nitrogen temperatures and subsequent sublimation. The controlled ice formation drives the segregation of every solute or colloid originally dispersed in the aqueous phase towards the zones in which the ice is absent, giving rise to areas where the ice resided before sublimation, resulting in an organized 3D scaffold. The results indicate that PVA/HA obtained by F/T exhibit the mechanical and swelling characteristics suitable for the use as articular cartilage replacement. In addition, the scaffold obtained by ISISA revealed the influence of the freezing rate on the final morphology, mechanical and swelling properties, mechanical and swelling properties. Finally, similar studies were done for scaffolds obtained by the combination of both techniques.